A team of University of Texas researchers is researching a potential new drug as an anti-corona virus, and the drug, known as piperidil, is used to treat a heart condition called angina.
According to a report by "sciencedaily", the team leader, a chemistry professor at Texas A&M University, says that it obtained approval from the US Food and Drug Administration in the 1990s, and if Piperidil eventually obtained a permit to treat Corona, it would be only the second treatment approved by the FDA. For the virus besides Remdesivir.
Liu said: “Most of the time when you reuse the medicines, you will find something, but a lot of the time these medicines are not that effective, but the medicine“ Pepperidil ”turns out to be exceptional, it has shown a really high effectiveness in preventing the virus from replicating in cells. ".
The team used artificial intelligence to scan drugs that had already received FDA approval to see which drugs could work against COVID-19, and then run their own experiments to confirm the results.
"We targeted the only enzyme necessary for the virus to reproduce in the human cell," Liu said. "Then we used a computer to check the drugs approved by the FDA and see which ones can incubate this specific enzyme." "Then we tested a true Coronavirus infection on a human cell to demonstrate that piperidil is only truly effective in preventing the virus from replicating within a human cell host."
Liu believes that bepredil could be a more promising treatment than Remdesivir because it received FDA approval for a much longer period of time, so doctors and scientists have the drug's long-term effect, and Remdesivir was granted FDA approval less than five months ago in October 2020.
Liu said, “Bepredil is a slightly different story because it was an established drug for about 30 years.” We know that it is very effective in treating heart disease, and we know enough about the human metabolism of this drug inside the body, adding I think that bepredil will have a better chance Remdesivir in the fight against Corona.
Liu's team is working with another team from the University of Texas Medical Branch (UTMB) on this research, and the research team has received approval to test the drug in mice in animal experiments, and they are already discussing what human clinical trials might look like.
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